Carcinoma Primário de Células Renais

RESIRT foi o primeiro teste em humanos para avaliar o SIRT para o tratamento do carcinoma primário de células renais (CCR). Este estudo piloto com 21 pacientes demonstrou boa tolerabilidade das microesferas de resina SIR-Spheres® Y-90 em todos os níveis de dose no tratamento de tumores primários em pacientes com CCR, caso contrário, inadequados para terapia convencional. Não houve toxicidade limitante de dose e nenhum evento adverso grave (SAEs) ou SAEs relacionados às microesferas de resina SIR-Spheres Y-90. As melhores respostas globais do tumor foram resposta parcial (RP) em 1/20 (5%), doença estável (SD) em 18/20 (90%) e doença pseudoprogressiva em 1/20 (5%). O estudo RESIRT sugere que as microesferas de resina SIRT com SIR-Spheres Y-90 podem ser uma opção de tratamento viável para pacientes com CCR que são inadequados para terapia convencional, e mais estudos clínicos são garantidos.1

1 Clark, W. et al. Society of Interventional Radiology (SIR) 42nd Annual Scientific Meeting, J Vasc Interv Radiol 2017; 28 (Suppl): S164 Abs. 379.

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