Principais Conclusões

Microesferas de resina SIR-Spheres® Y-90 + mFOLFOX6 +/- biológico *

  • não adicionou um benefício em Overall Survival1, mas:
  • Taxa de resposta significativamente aumentada e sobrevida livre de progressão mediana no fígado, 1,2
  • resultou em uma melhora clinicamente relevante na Sobrevida Global em pacientes com metástases hepáticas de tumores primários do lado direito (RSP),
  • mostrou um perfil de segurança e tolerabilidade conforme esperado e gerenciável.

     

*Bevacizumab em SIRFLOX e FOXFIRE Global, bevacizumab ou cetuximab em FOXFIRE e biológicos permitidos à discrição do investigador, por prática institucional.

1. Wasan HS et al. Lancet Oncol 2017; 18: 1159-71
2. Van Hazel G et al. J Clin Oncol 2016; 34:1723–1731.


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