Click here for further information on ongoing studies with SIR-Spheres® Y-90 resin microspheres on www.clinicaltrials.gov
Liver Metastases
| Title | Setting | Sponsor | Study ID | Treatment Arm(s) | N | Location |
|---|---|---|---|---|---|---|
| TAS-102 and radioembolisation with SIR-Spheres Y-90 resin microspheres for chemorefractory colorectal liver metastases | Chemorefractory mCRC | Investigator initiated study | NCT02602327 | TAS 102 + SIR-Spheres Y-90 resin microspheres | 24 | USA |
| SIRTAC SIR-Spheres Y-90 resin microspheres vs. TACE treatment of uveal melanoma metastazised to liver |
Uveal melanoma liver metastasis | Investigator initiated study | NCT02936388 | SIR-Spheres Y-90 resin microspheres vs. TACE (cisplatin+embocept) | 108 | Germany |
| A feasibility study of sequential hepatic internal radiation and systemic ipilimumab and nivolumab in patients with uveal melanoma metastatic to liver | Uveal melanoma liver metastasis | Investigator initiated study | NCT02913417 | Sequential SIR-Spheres Y-90 resin microspheres > ipilimumab + nivolumab > nivolumab | 18 | USA |
Primary Liver Cancer
| Title | Setting | Sponsor | Study ID | Treatment Arm(s) | N | Location |
|---|---|---|---|---|---|---|
| Study of Y-90 radioembolisation with nivolumab in Asians with hepatocellular carcinoma | Hepatocellular carcinoma | Investigator initiated study | NCT03033446 | SIR-Spheres Y-90 resin microspheres > nivolumab | 40 | Singapore |
| NASIR-HCC A study of the safety and antitumoral efficacy of nivolumab after SIRT for the treatment of patients with HCC |
Hepatocellular carcinoma | Investigator initiated study | NCT03380130 | SIR-Spheres Y-90 resin microspheres > nivolumab | 40 | Spain |
| SIRCCA SIRT followed by CIS-GEM chemotherapy versus CIS-GEM chemotherapy alone as 1st line treatment of patients with unresectable intrahepatic cholangiocarcinoma |
Intrahepatic cholangiocarcinoma | Sirtex | NCT02807181 | SIR-Spheres Y-90 resin microspheres > cisplatin + gemcitabine vs. cisplatin + gemcitabine | 180 | Global |
| STOCS This study aims to study the benefits of sequential administration of SIRT followed by standard chemotherapy for treatment of inoperable intrahepatic cholangiocarcinoma |
Intrahepatic cholangiocarcinoma | Investigator initiated study | NCT02167711 | SIR-Spheres Y-90 resin microspheres > gemcitabine + cisplatin | 24 | Hong Kong Singapore Thailand |
| MIRD Current experience on yttrium-90 radioembolisation utilising resin microspheres with MIRD-model dosimetry |
Intrahepatic cholangiocarcinoma and Hepatocellular carcinoma with portal vein invasion | Investigator initiated study | not registered | SIR-Spheres Y-90 resin microspheres | 25 | USA |
Liver Metastases and Primary Liver Cancer
| Title | Setting | Sponsor | Study ID | Treatment Arm(s) | N | Location |
|---|---|---|---|---|---|---|
| AROMA Abscopal effects after radioembolisation of metastatic colorectal cancer |
mCRC, HCC, mBC | Investigator initiated study | not registered | SIR-Spheres Y-90 resin microspheres | 60 | Germany |
Registries
| Title | Setting | Sponsor | Study ID | Treatment Arm(s) | N | Location |
|---|---|---|---|---|---|---|
| CIRT-FR CIRSE registry for SIR-Spheres therapy in France |
Primary and secondary liver tumors | CIRSE | NCT03256994 | SIR-Spheres Y-90 resin microspheres | 200 | France |
| RESIN (USA) Yttrium Y-90 resin microspheres data collection in unresectable liver cancer: the RESIN study |
Primary and secondary liver tumors | Investigator initiated study | NCT02685631 | SIR-Spheres Y-90 resin microspheres | 3000 | USA |
| ESSURE European SIR-Spheres Surgical Registry |
Primary and secondary liver tumors | Investigator initiated study | not registered | SIR-Spheres Y-90 resin microspheres | 250 | Germany |
| BSIR SIRT Registry British Society of Interventional Radiology |
Primary and secondary liver tumors | Investigator initiated study | not registered | SIR-Spheres Y-90 resin microspheres | UK | |
| RESIN (Taiwan) REgistry of Selective Internal radiation therapy in TaiwaN |
Hepatocellular carcinoma | Investigator initiated study | NCT03292991 | SIR-Spheres Y-90 resin microspheres | 100 | Taiwan, Singapore, Thailand |
| RESiN (ANZ) Radiation-Emitting SIR-Spheres in Non-resectable Liver Tumor |
Primary and secondary liver tumors | Investigator initiated study | not registered | SIR-Spheres Y-90 resin microspheres | >150 | Australia and New Zealand |