Primary tumor location was captured prospectively for 739 patients in the SIRFLOX and FOXFIRE Global studies:
- Right-sided primary (RSP) tumors were defined as any primary tumor proximal to the splenic flexure
- Left-sided primary (LSP) tumors included any primary tumor at the splenic flexure, the more distal colon or the rectum
Overall survival and progression-free survival data were examined independently for patients with RSP and LSP.
Tumor response was determined according to Response Evaluation Criteria In Solid Tumours (RECIST) version 1.0.
All analyses were performed on the intention-to-treat population.
Gibbs P et al. Clin Col Cancer 2018 Jun 12 ePub: doi: 10.1016/j.clcc.2018.06.001.