Selective Internal Radiation Therapy (SIRT), also known as Radioembolization, is a liver-directed therapy for inoperable liver tumors.  SIRT is typically a 2-stage process. It requires the involvement of a multi-disciplinary team consisting of representatives from most, if not all of the following specialities: Medical Oncology, Surgical Oncology, Gastroenterology / Hepatology, Nuclear Medicine, Interventional Radiology and Radiation Safety.

A microcatheter is used to deliver millions of radioactive microspheres into the hepatic artery, where they are carried into the arterioles and selectively lodge in the tumor microvasculature (for further information see Mode of Action).

The SIRT procedure targets liver tumors directly and enables high doses of radiation to the tumor tissue by using the special tumor's blood supply. Healthy liver tissue derives up to 90% of its blood from the portal vein, with only a small amount of the blood coming from the hepatic artery. In contrast, liver tumors derive up to 90% of their blood from the hepatic artery since they need a profuse supply of highly oxygenated blood. The hepatic artery therefore provides an ideal channel for a targeted tumor treatment.

Treatment Goals

  • Increase the time to progression
  • Extend overall survival
  • Potentially downsize or downstage tumors for liver resection, ablation, or transplantation
  • Provide palliation of symptoms

SIRT can be combined with modern chemotherapy or administered as a monotherapy, either during a chemotherapy-free interval, in a salvage setting or as an alternative to local or systemic treatments.

 




Now leaving sirtex.com

You are about to leave the Sirtex Web site. This link is provided to you as a service and will take you to a site maintained by a third party who is solely responsible for the content.

Please be aware that Sirtex takes no responsibility for content of these external sites, nor do we endorse, warrant or guarantee the products, services or information described or offered on other internet sites.

Click 'Continue' to proceed to the third-party Web site.

Continue

×

You are now leaving your current sirtex.com region

The Sirtex site you are linking to is intended only for healthcare practitioners and patients outside your current region. Any products discussed herein may have different approved product labeling; therefore, any information provided may not be appropriate for use in your region.

Click 'Continue' to proceed to the other Sirtex region Web site.

Continue

×