Key Inclusion Criteria

  • Adenocarcinoma of the colon or rectum
  • Liver metastases not surgically resectable or ablatable (determined by local MDT)
  • Limited extra-hepatic metastases allowed in the lung or lymph nodes (protocol specific definition, by CT scan)
  • Aged ≥18 years
  • WHO Performance Status 0 – 1
  • Life expectancy ≥3 months without any active treatment
  • No prior chemotherapy except for adjuvant chemotherapy completed ≥6 months prior
  • Deemed suitable for either treatment regimen by the investigator
  • Adequate hematological, renal and hepatic function
  • Using an acceptable method of contraception

Key Exclusion Criteria

  • Evidence of ascites, cirrhosis, portal hypertension, main portal vein tumor involvement or portal vein thrombosis
  • Previous radiotherapy delivered to the upper abdomen
  • Non-malignant disease that renders patients unsuitable for the study treatment
  • Peripheral neuropathy grade > 1 (NCI-CTCv3)
  • Previous dose-limiting toxicity associated with adjuvant 5-FU or oxaliplatin chemotherapy
  • Pregnancy or breast feeding
  • Concurrent or previous malignancy other than adequately treated non-melanoma skin cancer or carcinoma in situ of the cervix
  • Allergy to non-ionic contrast agents

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