SIR-Spheres® Y-90 resin microspheres
About SIR-Spheres
SIR-Spheres Y-90 resin microspheres are a permanent implant and for single use only.
The high number of microspheres provide a uniform radiation distribution, enabling treatment of solitary and multifocal liver tumors.1–3
With a specific density close to that of red-blood cells,1 they are carried by the blood flow, penetrating deep into the tumor microvasculature.
SIR-Spheres can therefore be delivered in a slow, deliberate manner:
- to achieve an even distribution
- to maximize the number of microspheres delivered
- to optimize tumor coverage - even in patients with extensive disease
Yttrium-90 has two inherent safety features for staff and patients:
- the minimal penetration depth of beta radiation emissions through tissue and air
- the relatively short half-life of 64.1 hours
Product Features |
|
| Manufacturer | Sirtex Medical Pty Ltd |
| Isotope | Yttrium-90 |
| Decay product | Zirconium-90 |
| Composition | Resin (sulfonated divinyl benzene-styrene copolymer) |
| Specific density | 1.125-1.6 g/ml (comparable to red blood cells) |
| Diameter | 32±10 µm |
| T1/2 | 64.1 h (94% within 11 days) |
| Penetration in tissue | 2.5 mm (mean) |
| Presentation of activity | Single dose size containing 3.0 GBq ± 10% of Y-90 at calibration date & time in 5 ml water for injection, moist sterilized. |
| No. of microspheres per vial | 44 (± 2.6) million |
Additional Product Information
- Sirtex internal data
- Burrill J et al. J Nucl Med Radiat Ther 2011; 2:107. doi:10.4172/2155-9619.1000107.
- Chiesa et al. J Nuc Med Molmaging 2011; 55: 168–197.