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SIR-Spheres® Y-90 resin microspheres

About SIR-Spheres

About SIRT

SIR-Spheres Y-90 resin microspheres are a permanent implant and intended for single use only.

The high number of microspheres provides a uniform radiation distribution, enabling treatment of solitary and multifocal liver tumors.1–3

With a specific density close to that of red blood cells,1 they are carried by the blood flow, penetrating deep into the tumor microvasculature.

Yttrium-90 has two inherent safety features for staff and patients:

  • the minimal penetration depth of beta radiation emissions through tissue  and air
  • the relatively short half-life of 64.1 hours

SIR-Spheres Y-90 resin microspheres can therefore be delivered in a slow, deliberate manner

  • to achieve an even distribution
  • to maximize the number of microspheres delivered
  • to optimize tumor coverage - even in patients with extensive disease
Product Features
  
Manufacturer Sirtex Medical Pty. Ltd
Isotope Yttrium-90
Decay product Zirconium-90
Composition Resin (sulfonated divinyl benzene-styrene copolymer)
Specific density 1.125 - 1.6 g/ml (comparable to red blood cells)
Diameter 32±10 µm
T1/2 64.1 h (94% within 11 days)
Penetration in tissue 2.5 mm (mean)
Presentation of activity
SIR-Y001: 3 GBq or 81 mCi per vial +/- 10% at the time of calibration
SIR-Y002: 1.8 GBq or 48.7 mCi per vial +/- 10% at the time of calibration
No. of microspheres per vial
SIR-Y001: ~44 million microspheres (with a standard deviation of 2.6 million) FR-006
SIR-Y002: 27.3 million microspheres (MS-TR-008)

 

Additional Product Information

  1. Sirtex internal data
  2. Burrill J et al. J Nucl Med Radiat Ther 2011; 2:107. doi:10.4172/2155-9619.1000107.
  3. Chiesa et al. J Nuc Med Molmaging 2011; 55: 168–197.
Indications for Use: SIR-Spheres Y-90 resin microspheres are indicated for the treatment of unresectable metastatic liver tumors from primary colorectal cancer with adjuvant intrahepatic artery chemotherapy (IHAC) of FUDR (Floxuridine). Consult the Instructions for Use for a complete listing of indications, contraindications, side effects, warnings, and precautions.