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SIR-Spheres® Y-90 resin microspheres

About SIR-Spheres

About SIRT

SIR-Spheres Y-90 resin microspheres are a permanent implant and intended for single use only.

The high number of microspheres provides a uniform radiation distribution, enabling treatment of solitary and multifocal liver tumors.1–3

With a specific density close to that of red blood cells,1 they are carried by the blood flow, penetrating deep into the tumor microvasculature.

Yttrium-90 has two inherent safety features for staff and patients:

  • the minimal penetration depth of beta radiation emissions through tissue  and air
  • the relatively short half-life of 64.1 hours

SIR-Spheres Y-90 resin microspheres can therefore be delivered in a slow, deliberate manner

  • to achieve an even distribution
  • to maximize the number of microspheres delivered
  • to optimize tumor coverage - even in patients with extensive disease
Product Features
  
Manufacturer Sirtex Medical Pty. Ltd
Isotope Yttrium-90
Decay product Zirconium-90
Composition Resin (sulfonated divinyl benzene-styrene copolymer)
Specific density 1.125 - 1.6 g/ml (comparable to red blood cells)
Diameter 32±10 µm
T1/2 64.1 h (94% within 11 days)
Penetration in tissue 2.5 mm (mean)
Presentation of activity
SIR-Y001: 3 GBq or 81 mCi per vial +/- 10% at the time of calibration
SIR-Y002: 1.8 GBq or 48.7 mCi per vial +/- 10% at the time of calibration
No. of microspheres per vial
SIR-Y001: ~44 million microspheres (with a standard deviation of 2.6 million) FR-006
SIR-Y002: 27.3 million microspheres (MS-TR-008)

 

Additional Product Information

  1. Sirtex internal data
  2. Burrill J et al. J Nucl Med Radiat Ther 2011; 2:107. doi:10.4172/2155-9619.1000107.
  3. Chiesa et al. J Nuc Med Molmaging 2011; 55: 168–197.