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SIR-Spheres® Y-90 resin microspheres

About SIRT

Selective internal radiation therapy (SIRT), also known as radioembolization, is a liver-directed therapy and is typically a two-stage process – the work-up and the treatment.

It requires the involvement of a multidisciplinary team consisting of representatives from most, if not all, of the following specialties: Medical Oncology, Surgical Oncology, Gastroenterology / Hepatology, Nuclear Medicine, Interventional Radiology/Oncology, and Radiation Safety.

SIRT targets liver tumors directly with locally applied radiation, while sparing healthy liver tissue, by using the special tumor's blood supply.

Healthy liver tissue derives about two-thirds of its blood from the portal vein, with one-fifth to one-third of the blood coming from the hepatic artery.1

In contrast, liver tumors derive up to 90% of their blood from the hepatic artery, since they need a profuse supply of highly oxygenated blood. The hepatic artery therefore provides an ideal channel for a targeted tumor treatment.

Treatment Goals

  • Increase the time to progression.
  • Extend overall survival.
  • Potentially downsize or downstage tumors for liver resection, ablation or transplantation.
  • Provide palliation of symptoms.

Administration

SIR-Spheres® Y-90 resin microspheres are administered under local anesthesia by a specially trained healthcare professional who​:

  • makes a small incision, either into the femoral artery near the groin (A) or the radial artery (A')​.
  • guides a microcatheter to the pre-specified site in the hepatic artery (B) (as identified during the pre-treatment planning).
  • administers SIR-Spheres through this catheter.
SIRT Treatment

1. Lautt WW. Hepatic Circulation: Physiology and Pathophysiology. Morgan & Claypool Life Sciences; 2009.

Indications for Use: SIR-Spheres Y-90 resin microspheres are indicated for the treatment of unresectable metastatic liver tumors from primary colorectal cancer with adjuvant intrahepatic artery chemotherapy (IHAC) of FUDR (Floxuridine). Consult the Instructions for Use for a complete listing of indications, contraindications, side effects, warnings, and precautions.