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SIR-Spheres® Y-90 resin microspheres

About SIR-Spheres

SIR-Spheres® Y-90 resin microspheres are a medical device used in selective internal radiation therapy (SIRT).

About SIR-Spheres
  • The microspheres are extremely small resin beads, approximately 32 microns in diameter, about a third of the width of a human hair.
  • They have a density similar to that of blood cells which allows them to travel easily within the bloodstream.
  • Y-90 resin microspheres contain the radioactive element yttrium-90, which delivers radiation over a relatively short distance in human tissue.

SIR-Spheres® Y-90 resin microspheres work from the inside, targeting radiation to the tumors.

  • When given with chemotherapy, SIR-Spheres may shrink liver tumors more than chemotherapy given alone.1,2
  • In some patients, SIR-Spheres  may shrink the tumors enough that they can be removed by surgery at a later date.2-4
  • Scientific studies have shown that treatment with SIR-Spheres may help you feel better and live longer.1,3,4
1. Wasan et al. Lancet Oncol 2017; 18: 1159–1171.
2. Garlipp B et al. Br J Surg 2019; 106: 1837-1846.
3. Cosimelli M et al. Br J Cancer 2010; 103: 324–331.
4. Sharma R et al. J Clin Oncol 2007; 25: 1099–1106.


Indications for Use: SIR-Spheres Y-90 resin microspheres are indicated for the treatment of unresectable metastatic liver tumors from primary colorectal cancer with adjuvant intrahepatic artery chemotherapy (IHAC) of FUDR (Floxuridine). Consult the Instructions for Use for a complete listing of indications, contraindications, side effects, warnings, and precautions.